A limited set of actions can assigned via macro commands. Incompatible actions are ommited from the generated macro. Also note that Macros are limited to 15 lines each.
A SMN layout that makes sense for my brain and how I play. Single Target on main, AoE on hotbar 2, which I usually switch to by hitting right bumper (R1) and then staying on that hotbar as needed.
Updated for 7.0!
Based on Squintina's layout, but with tweaks that fit my brain better. ST on chotbar 1, AoE on chotbar 2. I hit R1 (right bumper) to change to the AoE and sit on that chotbar as needed. Since RDM is my Eureka job, I have Eureka Potion set to chotbar 3, LD
MMO Mouse, most actions on 2 hotbars for easy Ctrl toggling
https://imgur.com/a/Eym6nDe
Mouse binds F1-F11, ESC Unused mouse buttons free to use (Mounts, LB,...)
HB 1&2: 6x2 on top of eachother HB3: 3x4 on the right of the other 2 Aether Currents = Compass
HB1: ↑ 1-4, ↑ Q, ↑ E
3 is for AOE combo > R1 to cycle 1 is Standard Combo (Single Target) > Main R1 to cycle 2 is for Role skills, dash, limit break