A limited set of actions can assigned via macro commands. Incompatible actions are ommited from the generated macro. Also note that Macros are limited to 15 lines each.
this layout works for levelling from RDM unlock through Dawntrail. main crossbar is your single target spells & burst rotation, and the 2nd has your AOE spells
This layout works for levelling SMN from 1 through Dawntrail
In this layout, I grouped the attack Motifs & Muses together, along with their action buttons, and your normal single target & group attacks and separated them from the other normal/non-motif/non-muse attacks. That neatly left room for Smudge on the main
1st: 1,2,3,4,5,Q,E,R,F,C,V,T 2nd: same but shift+
Tweaked the layout that got me from 80-90, still a work in progress.
Right side of LT/RT for instant cast actions, to make movement easier. Left side for things with cast timers and Scenic Muse, which has a long cooldown.
RT, RT for actions that are us
Rough layout based on my other caster hotbars. I use 1-5, F1-5 and 2 side mouse buttons.
LT=AOE RT=Single Target RTRT=Movement actions, mit, and buffs. LTLT=Role Actions and LB