A limited set of actions can assigned via macro commands. Incompatible actions are ommited from the generated macro. Also note that Macros are limited to 15 lines each.
smol
Picto Starter Layout
MMO Mouse, most actions on 2 hotbars for easy Ctrl toggling
1st: 1,2,3,4,5,Q,E,R,F,C,V,T 2nd: same but shift+
Rough layout based on my other caster hotbars. I use 1-5, F1-5 and 2 side mouse buttons.