A limited set of actions can assigned via macro commands. Incompatible actions are ommited from the generated macro. Also note that Macros are limited to 15 lines each.
I'm a left arm amputee - for 1-handed MMO mouse use (Logitech G600).
Rough layout based on my other caster hotbars. I use 1-5, F1-5 and 2 side mouse buttons.
Picto Starter Layout
PCT Controller Layout that makes sense to me.
AoE and Support Skills on 2nd Hotbar (Plus Sprint + LB bc space) Motifs/Muses/Single Target on Hotbar 1