A limited set of actions can assigned via macro commands. Incompatible actions are ommited from the generated macro. Also note that Macros are limited to 15 lines each.
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MMO Mouse, most actions on 2 hotbars for easy Ctrl toggling
A first run of a layout, influenced by my SMN and RDM layouts. ST on hotbar one, AoE on hotbar 2, other stuff on 3. I usually sit on either hotbar 1 or 2, depending on my needs, and switch between them with the R1 bumper.
1st: 1,2,3,4,5,Q,E,R,F,C,V,T 2nd: same but shift+
https://imgur.com/a/Eym6nDe