A limited set of actions can assigned via macro commands. Incompatible actions are ommited from the generated macro. Also note that Macros are limited to 15 lines each.
MMO Mouse, most actions on 2 hotbars for easy Ctrl toggling
eDit
In this layout, I grouped the attack Motifs & Muses together, along with their action buttons, and your normal single target & group attacks and separated them from the other normal/non-motif/non-muse attacks. That neatly left room for Smudge on the main
LT=AOE RT=Single Target RTRT=Movement actions, mit, and buffs. LTLT=Role Actions and LB