A limited set of actions can assigned via macro commands. Incompatible actions are ommited from the generated macro. Also note that Macros are limited to 15 lines each.
this layout I put together while learning and levelling, adding new spells as they unlock. It's not perfect, it's a bit all over the place, for example, the Muses & Motifs aren't grouped together, or even in the same position across the cross-bars, so I'd
https://imgur.com/a/Eym6nDe
1st: 1,2,3,4,5,Q,E,R,F,C,V,T 2nd: same but shift+
First attempt to make panels for MMO mouse with 2 3x4 hotbars and 1 6x2 for utility