A limited set of actions can assigned via macro commands. Incompatible actions are ommited from the generated macro. Also note that Macros are limited to 15 lines each.
I got used to starting my rotations from right to left.
This layout is meant to be used with any sort of MMO mouse that has 12 buttons on the side. I chose 4x3 bars so that the layout represents the button layout on my mouse.
Bar 1 encompasses your single-target rotation. I was aiming for as little thumb
Prime Tank
Core / Frequent Action items focused on Hotbar 1 (ST 1-6 & AoE 7-12) Secondary Actions/Buffs/Debuffs found on Hotbars 2 and 3